If you're a fan of cannabis or are interested in its potential health benefits, you may have heard of tetrahydrocannabinol (THC), the compound responsible for the plant's psychoactive effects. But have you heard of Hexahydrocannabinol (HHC)? HHC is a lesser-known cannabinoid found in cannabis that has been garnering attention for its potential therapeutic properties.
One of the main differences between HHC and THC is their chemical structure. While THC has a cyclohexene ring, HHC has a cyclohexane ring, which affects the way it interacts with the body's endocannabinoid system. HHC is also not as well-studied as THC, and its effects on the body are not yet fully understood.
However, early research suggests that HHC may have potential as a therapeutic agent for a range of health conditions. For example, a study published in the journal ACS Medicinal Chemistry Letters found that HHC has potent analgesic and anti-inflammatory properties, making it a promising alternative to traditional pain medications.
HHC may also have potential as an anxiolytic, or anxiety-reducing agent. Studies in animal models have shown that HHC has anxiolytic effects without producing the sedative effects of other cannabinoids like THC. This could make HHC an attractive option for individuals who experience anxiety but do not want to feel drowsy or impaired.
While research on HHC is still in its early stages, its potential therapeutic properties make it an exciting area of study for the medical cannabis community. At Molecule, we are dedicated to staying up-to-date on the latest research in this field, and we look forward to seeing what the future holds for HHC and other cannabinoids.
Chemical structure differences between THC and HHC: "Cannabinoid Chemistry: An Introduction." Chemistry LibreTexts. Accessed May 3, 2023. https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_(Organic_Chemistry)/Cannabinoids/1%3A_Cannabinoid_Chemistry%3A_An_Introduction.
Analgesic and anti-inflammatory properties of HHC: Kulkarni, P.M., Kulkarni, A.R., Wadher, S.J. et al. "Design, synthesis and evaluation of hexahydrocannabinol analogs as potent anti-inflammatory agents." ACS Medicinal Chemistry Letters 3, 439–443 (2012). https://doi.org/10.1021/ml200283k.
Anxiolytic effects of HHC without sedative effects: Osório, F.L., Sanches, R.F., Macedo, L.R. et al. "Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report." Revista Brasileira de Psiquiatria 37, 13–20 (2015). https://doi.org/10.1590/1516-4446-2014-1496.